04-P001 Noggin2 can modulate activin signaling and is essential for normal forebrain development

Noggin1 is a famous embryonic neural inducer that can sequester TGF-beta cytokines of Bone Morphogenetic Protein family, thereby antagonizing Smad1-dependent signaling pathway activity. During early embryogenesis noggin1 executes two major biological functions: conversion of embryonic mesoderm into skeletal muscles (dorsalization) and of ectoderm into neural tissue (neuralization). Anterior neu...

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04-P003 Induction of cranial placodes: The role of ectodermal competence

Noggin1 is a famous embryonic neural inducer that can sequester TGF-beta cytokines of Bone Morphogenetic Protein family, thereby antagonizing Smad1-dependent signaling pathway activity. During early embryogenesis noggin1 executes two major biological functions: conversion of embryonic mesoderm into skeletal muscles (dorsalization) and of ectoderm into neural tissue (neuralization). Anterior neu...

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04-P002 Axis determination in the early chick embryo

Noggin1 is a famous embryonic neural inducer that can sequester TGF-beta cytokines of Bone Morphogenetic Protein family, thereby antagonizing Smad1-dependent signaling pathway activity. During early embryogenesis noggin1 executes two major biological functions: conversion of embryonic mesoderm into skeletal muscles (dorsalization) and of ectoderm into neural tissue (neuralization). Anterior neu...

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ERK Signaling Is Essential for Macrophage Development

Macrophages depend on colony stimulating factor 1 (also known as M-CSF) for their growth and differentiation, but the requirements for intracellular signals that lead to macrophage differentiation and function remain unclear. M-CSF is known to activate ERK1 and ERK2, but the importance of this signaling pathway in macrophage development is unknown. In these studies, we characterized a novel mod...

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Cripto forms a complex with activin and type II activin receptors and can block activin signaling.

Activin, nodal, Vg1, and growth and differentiation factor 1 are members of the transforming growth factor beta superfamily and signal via the activin type II (ActRII/IIB) and type I (ALK4) serine/threonine kinase receptors. Unlike activins, however, signaling by nodal, Vg1, and growth and differentiation factor 1 requires a coreceptor from the epidermal growth factor-Cripto-FRL1-Cryptic protei...

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04-P001 Noggin2 can modulate activin signaling and is essential for normal forebrain development

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